Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483.
作者信息
Bonjoch J, Diaba F, Puigbó G, Solé D, Segarra V, Santamaría L, Beleta J, Ryder H, Palacios J M
机构信息
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Spain.
出版信息
Bioorg Med Chem. 1999 Dec;7(12):2891-7. doi: 10.1016/s0968-0896(99)00250-3.
Abstract
The synthesis of an azaspirocyclic analogue of FR901483, phosphate 2, is described based on the implementation of a key 5-endo aminocyclization promoted by iodine for direct functionalization of the 1-azaspiro[4.5]decane ring at the C-3 atom. Compound 2 has no inhibitory activity in the cell proliferation assays reported.
摘要
Zotero 插件