Total synthesis of FR901483.

作者信息

Ousmer M, Braun N A, Ciufolini M A

机构信息

Laboratoire de Synthèse et Méthodologie Organiques, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, 43, Bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.

出版信息

Org Lett. 2001 Mar 8;3(5):765-7. doi: 10.1021/ol015526i.

DOI:10.1021/ol015526i

PMID:11259057

Abstract

[structure: see text]. The total synthesis of FR901483, a structurally novel immunosuppressant, has been accomplished by the use of technology recently developed in this laboratory for the oxidative cyclization of phenolic oxazolines to spirolactams. Our approach may reflect the biosynthetic pathway leading to the natural product.

摘要