Duhamel G, Muratore R, Bryon P
Nouv Rev Fr Hematol (1978). 1976 Jun;16(1):81-6.
77 marrow biopsies of smouldering leukemia have been examined in triple blind fashion with the following results: the cellularity of the marrow is normal in three quarters of the cases. In one quarter the blast cells were homogenous, which confirms the diagnosis of leukemia. The frequences of the sheets of blast cells increase with the duration of the disease and reached 80% at the 20th month. In the other cases, blasts were seldom seen. Eosinophilia was frequent. Erythroblasts were always rare, in contrast to what is seen in sideroblastic anemias. The reticulin network was thickened in 25% of the cases. Thus, bone marrow biopsy may demonstrate many of the features supporting the diagnosis of smouldering leukemia.
对77例冒烟型白血病的骨髓活检进行了三盲法检查，结果如下：四分之三的病例骨髓细胞密度正常。四分之一的病例原始细胞均匀一致，这证实了白血病的诊断。原始细胞片层的频率随疾病持续时间增加，在第20个月时达到80%。在其他病例中，很少见到原始细胞。嗜酸性粒细胞增多很常见。与铁粒幼细胞贫血所见相反，成红细胞总是很少见。25%的病例网状纤维网络增粗。因此，骨髓活检可显示许多支持冒烟型白血病诊断的特征。
