McCaffery J M, Pogue-Geile M F, Debski T T, Manuck S B
Department of Psychology, University of Pittsburgh, Pennsylvania 15260, USA.
J Hypertens. 1999 Dec;17(12 Pt 1):1677-85. doi: 10.1097/00004872-199917120-00004.
To determine the extent to which the correlation of systolic blood pressure, diastolic blood pressure, body mass, fasting total cholesterol and fasting triglycerides in young adulthood reflects common genetic or environmental influences.
Cardiovascular risk factors were measured in a community sample of 129 monozygotic and 67 dizygotic twin pairs, ages 18-30 years.
Multivariate twin structural equation modelling allows estimation of the extent to which the covariation of two or more variables is attributable to common genetic and environmental factors and was used to analyse the correlation among systolic blood pressure, diastolic blood pressure, body mass index, fasting total cholesterol and triglycerides.
The covariation of risk factors was partially attributable to a single common genetic factor, while the covariation of systolic blood pressure, body mass index and triglycerides was also, in part, attributable to a common non-shared environmental factor.
Genetic and, to a lesser extent, non-shared environmental factors contribute to the covariation of cardiovascular risk factors in young adult twins. Nonetheless, it should be noted that these common influences account for a relatively small percentage of the variance in each risk factor compared to genetic and environmental factors that are risk factor-specific.
确定青年期收缩压、舒张压、体重、空腹总胆固醇和空腹甘油三酯之间的相关性在多大程度上反映了共同的遗传或环境影响。
在一个由129对同卵双胞胎和67对异卵双胞胎组成的社区样本中测量心血管危险因素，这些双胞胎年龄在18至30岁之间。
多变量双胞胎结构方程模型可用于估计两个或多个变量的协方差在多大程度上可归因于共同的遗传和环境因素，并用于分析收缩压、舒张压、体重指数、空腹总胆固醇和甘油三酯之间的相关性。
危险因素的协方差部分归因于单一的共同遗传因素，而收缩压、体重指数和甘油三酯的协方差部分也归因于一个共同的非共享环境因素。
遗传因素以及在较小程度上非共享环境因素导致了青年双胞胎心血管危险因素的协变。尽管如此，应该注意的是，与特定危险因素的遗传和环境因素相比，这些共同影响在每个危险因素的方差中所占比例相对较小。
