Jedrusik P, Januszewicz A, Busjahn A, Zawadzki B, Wocial B, Ignatowska-Switalska H, Berent H, Kuczyńska K, Oniszczenko W, Strelau J, Luft F C, Januszewicz W
Department of Internal Medicine and Hypertension, Warsaw Medical University, Poland.
Blood Press. 2003;12(1):7-11.
We studied 76 healthy monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs (mean age 35 +/- 8 years, body mass index, BMI, 23.6 +/- 3.9 kg/m2) to determine genetic and environmental contributions to systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR) and serum lipids [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-chol), high-density lipoprotein cholesterol (HDL-chol) and triglycerides (TG)I. SBP, DBP and HR were measured clinically and by ambulatory blood pressure monitoring (ABPM). Parameters of the genetic models for age-, sex- and BMI-adjusted data were estimated by model fitting and path analysis technique using LISREL 8. We found significant genetic effect on SBP and DBP for both clinical and ABP measurements, ranging from 37% for night-time ambulatory DBP to 79% for daytime ambulatory SBP. Estimates of genetic effects were higher for daytime than night-time ABP values, and higher for ambulatory 24-h SBP than office SBP measurements, with the reverse true for DBP. Significant genetic effect on HR ranged from 59% for office measurements to 69% for 24-h mean values. In summary, we also found genetic effect on TC, LDL-chol and HDL-chol with estimates ranging from 36% to 64%, but not on TG. Furthermore, a shared environmental component for TG was found, estimated at 36%. We showed significant genetic effect on both office and ambulatory BP and HR, with stronger genetic effect on daytime than night-time BP. We also found genetic effect on TC and lipoprotein fractions, but no significant genetic effect on TG. Environmental factors influencing serum TG, such as alcohol consumption, may explain the apparent lack of genetic effect in this healthy, non-obese population.
我们研究了76对健康的同卵双胞胎（MZ）和同性异卵双胞胎（DZ）（平均年龄35±8岁，体重指数，BMI，23.6±3.9kg/m²），以确定遗传和环境因素对收缩压（SBP）、舒张压（DBP）、心率（HR）和血脂[总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-chol）、高密度脂蛋白胆固醇（HDL-chol）和甘油三酯（TG）]的影响。SBP、DBP和HR通过临床测量和动态血压监测（ABPM）进行测量。使用LISREL 8，通过模型拟合和路径分析技术估计年龄、性别和BMI调整后数据的遗传模型参数。我们发现，临床和ABP测量中，SBP和DBP均存在显著的遗传效应，夜间动态DBP的遗传效应为37%，白天动态SBP的遗传效应为79%。白天ABP值的遗传效应估计高于夜间，24小时动态SBP的遗传效应高于诊室SBP测量值，DBP则相反。HR的显著遗传效应范围从诊室测量的59%到24小时平均值的69%。总之，我们还发现TC、LDL-chol和HDL-chol存在遗传效应，估计范围为36%至64%，但TG不存在遗传效应。此外，发现TG存在共享环境成分，估计为36%。我们表明，诊室和动态血压及心率均存在显著的遗传效应，白天血压的遗传效应强于夜间。我们还发现TC和脂蛋白组分存在遗传效应，但TG不存在显著遗传效应。影响血清TG的环境因素，如酒精摄入，可能解释了在这个健康、非肥胖人群中明显缺乏遗传效应的原因。
