范科尼贫血患者皮肤成纤维细胞中γ射线切除修复功能缺陷。
Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia.
作者信息
Remsen J F, Cerutti P A
出版信息
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2419-23. doi: 10.1073/pnas.73.7.2419.
Abstract
The capacity of preparations of skin fibroblasts from normal individuals and patients with Fanconi's anemia to excise gamma-ray products of the 5,6-dihydroxydihydrothymine type from exogenous DNA was investigated. The excision capacity of whole-cell homogenates of fibroblasts from two of four patients with Fanconi's anemia was substantially below normal. This repair deficiency was further pronounced in nuclear preparations from cells of the same two patients.
摘要
研究了正常个体和范可尼贫血患者的皮肤成纤维细胞制剂从外源DNA中切除5,6 - 二羟基二氢胸腺嘧啶类型的γ射线产物的能力。四名范可尼贫血患者中有两名患者的成纤维细胞全细胞匀浆的切除能力显著低于正常水平。在这两名患者细胞的细胞核制剂中，这种修复缺陷更为明显。
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Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia.范科尼贫血患者皮肤成纤维细胞中γ射线切除修复功能缺陷。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2419-23. doi: 10.1073/pnas.73.7.2419.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Gamma-ray induced damage in thymine in mononucleotide mixtures, and in single- and double-stranded DNA.γ射线对单核苷酸混合物以及单链和双链DNA中胸腺嘧啶的损伤。
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Excision of damaged thymine residues from gamma-irradiated poly(dA-dT) by crude extracts of Escherichia coli.利用大肠杆菌粗提取物从γ射线辐照的聚（dA-dT）中切除受损胸腺嘧啶残基
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Purification and some properties of a mammalian repair endonuclease.一种哺乳动物修复性核酸内切酶的纯化及某些特性
Biochim Biophys Acta. 1974 Jun 14;353(1):99-114. doi: 10.1016/0005-2787(74)90101-4.
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A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.范科尼贫血对DNA交联剂导致染色体断裂高度敏感。
Cancer Res. 1973 Aug;33(8):1829-36.
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