Bléry M, Olcese L, Vivier E
Centre d'immunologie INSERM-CNRS de Marseille-Luminy, France.
Hum Immunol. 2000 Jan;61(1):51-64. doi: 10.1016/s0198-8859(99)00157-3.
This review focuses on recent findings on the structural features of inhibitory NK cell receptors containing immunoreceptor tyrosine-based inhibition motif (ITIM) and of NK cell activating receptors, both in human and mouse. First, the study of the inhibitory killer cell immunoglobulin-like receptors (KIR) unveiled the presence of intracytoplasmic ITIM and their capacity to recruit protein tyrosine phosphatases such as SHP-1 in vivo. A brief summary of the known SHP-1 targets may help us to understand the inhibition mediated by the KIR. The characterization of ITIM thus allowed the definition of a large group of inhibitory cell surface receptors. The second part of the review describes the known NK cell activating receptors. Most of them require association with ITAM-containing polypeptides in order to mediate cell activation.
本综述聚焦于近期有关人和小鼠中含免疫受体酪氨酸抑制基序（ITIM）的抑制性自然杀伤（NK）细胞受体以及NK细胞激活受体结构特征的研究发现。首先，对抑制性杀伤细胞免疫球蛋白样受体（KIR）的研究揭示了其胞质内ITIM的存在及其在体内募集蛋白酪氨酸磷酸酶如SHP-1的能力。简要总结已知的SHP-1靶点可能有助于我们理解KIR介导的抑制作用。ITIM的特性鉴定使得一大类抑制性细胞表面受体得以定义。综述的第二部分描述了已知的NK细胞激活受体。它们中的大多数需要与含免疫受体酪氨酸激活基序（ITAM）的多肽结合才能介导细胞活化。
