Schmidt Stanislaw, Tramsen Lars, Rais Bushra, Ullrich Evelyn, Lehrnbecher Thomas
Division for Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.
Division of Stem Cell Transplantation and Immunology, Laboratory for Cellular Immunology, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt, Germany.
Oncotarget. 2018 Apr 17;9(29):20891-20907. doi: 10.18632/oncotarget.25058.
Natural Killer (NK) cells are involved in the host immune response against infections due to viral, bacterial and fungal pathogens, all of which are a significant cause of morbidity and mortality in immunocompromised patients. Since the recovery of the immune system has a major impact on the outcome of an infectious complication, there is major interest in strengthening the host response in immunocompromised patients, either by using cytokines or growth factors or by adoptive cellular therapies transfusing immune cells such as granulocytes or pathogen-specific T-cells. To date, relatively little is known about the potential of adoptively transferring NK cells in immunocompromised patients with infectious complications, although the anti-cancer property of NK cells is already being investigated in the clinical setting. This review will focus on the antimicrobial properties of NK cells and the current standing and future perspectives of generating and using NK cells as immunotherapy in patients with infectious complications, an approach which is promising and might have an important clinical impact in the future.
自然杀伤（NK）细胞参与宿主针对病毒、细菌和真菌病原体感染的免疫反应，这些病原体都是免疫功能低下患者发病和死亡的重要原因。由于免疫系统的恢复对感染并发症的结局有重大影响，因此人们对通过使用细胞因子或生长因子，或通过输入粒细胞或病原体特异性T细胞等免疫细胞的过继性细胞疗法来增强免疫功能低下患者的宿主反应有着浓厚兴趣。迄今为止，尽管NK细胞的抗癌特性已在临床环境中得到研究，但对于在患有感染并发症的免疫功能低下患者中过继性转移NK细胞的潜力了解相对较少。本综述将聚焦于NK细胞的抗菌特性，以及在患有感染并发症的患者中产生和使用NK细胞作为免疫疗法的现状和未来前景，这种方法很有前景，可能在未来产生重要的临床影响。
