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一种肽酶在吞噬细胞趋化作用中的作用。

Role of a peptidase in phagocyte chemotaxis.

作者信息

Aswanikumar S, Schiffmann E, Corcoran B A, Wahl S M

出版信息

Proc Natl Acad Sci U S A. 1976 Jul;73(7):2439-42. doi: 10.1073/pnas.73.7.2439.

DOI:10.1073/pnas.73.7.2439
PMID:1065899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430599/
Abstract

The potencies of N-formylmethionyl (fMet) peptides as chemotactic agents for phagocytes are related to the rates at which they are hydrolyzed. Furthermore, chloromethyl ketones inhibit chemotaxis as do the products of hydrolysis of fMet peptides. The directed migration of cells in response to such peptides is probably brought about by the binding of the peptide to a cell receptor with subsequent cleavage by peptidase specific for aromatic residues, a process that allows the chemical gradient to be detected.

摘要

N-甲酰甲硫氨酰（fMet）肽作为吞噬细胞趋化剂的效力与其水解速率有关。此外，氯甲基酮和fMet肽的水解产物一样能抑制趋化作用。细胞对这类肽的定向迁移可能是由肽与细胞受体结合，随后被对芳香族残基具有特异性的肽酶裂解所引起的，这一过程使得化学梯度能够被检测到。

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Role of a peptidase in phagocyte chemotaxis.一种肽酶在吞噬细胞趋化作用中的作用。
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本文引用的文献

1
Polymorphonuclear leukocyte chemotactic activity in rabbit serum and Guinea pig serum treated with immune complexes: evidence for c5a as the major chemotactic factor.兔血清和免疫复合物处理的豚鼠血清中的多形核白细胞趋化活性：C5a 是主要趋化因子的证据。
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A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.一种改进的分光光度法测定胰凝乳蛋白酶、胰蛋白酶和凝血酶。
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Partial biochemical characterization of the activated esterase required in the complement-dependent chemotaxis of rabbit polymorphonuclear leukocytes.兔多形核白细胞补体依赖性趋化作用中所需活化酯酶的部分生化特性
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4
Esterases of the polymorphonuclear leukocyte capable of hydrolyzing acetyl DL-phenyl-alanine beta-naphthyl ester. Relationship to the activatable esterase of chemotaxis.能够水解乙酰 DL - 苯丙氨酸β - 萘酯的多形核白细胞酯酶。与趋化性可激活酯酶的关系。
J Exp Med. 1969 Mar 1;129(3):569-84. doi: 10.1084/jem.129.3.569.
5
Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes.眼镜蛇毒因子与豚鼠补体的反应及多形核白细胞趋化活性的产生。
Proc Soc Exp Biol Med. 1969 May;131(1):203-7. doi: 10.3181/00379727-131-33840.
6
The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase.趋化因子对兔中性粒细胞的失活作用及可激活酯酶的性质。
J Exp Med. 1968 Apr 1;127(4):693-709. doi: 10.1084/jem.127.4.693.
7
Biochemical demonstration of the activatable esterase of the rabbit netrophil involved in the chemotactic response.参与趋化反应的兔嗜中性粒细胞可激活酯酶的生化证明。
J Immunol. 1970 Nov;105(5):1057-67.
8
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin.有丝分裂原刺激的人外周血淋巴细胞碳水化合物代谢的变化。I. 植物血凝素刺激
Biochim Biophys Acta. 1970 Dec 29;222(3):565-82. doi: 10.1016/0304-4165(70)90182-0.
9
Factors from saliva and oral bacteria, chemotactic for polymorphonuclear leukocytes: their possible role in gingival inflammation.来自唾液和口腔细菌的对多形核白细胞具有趋化作用的因子：它们在牙龈炎症中的可能作用。
J Periodontol. 1970 Feb;41(2):71-80. doi: 10.1902/jop.1970.41.2.71.
10
Chemoreceptors in bacteria.细菌中的化学感受器
Science. 1969 Dec 26;166(3913):1588-97. doi: 10.1126/science.166.3913.1588.