一种肽酶在吞噬细胞趋化作用中的作用。
Role of a peptidase in phagocyte chemotaxis.
作者信息
Aswanikumar S, Schiffmann E, Corcoran B A, Wahl S M
出版信息
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2439-42. doi: 10.1073/pnas.73.7.2439.
Abstract
The potencies of N-formylmethionyl (fMet) peptides as chemotactic agents for phagocytes are related to the rates at which they are hydrolyzed. Furthermore, chloromethyl ketones inhibit chemotaxis as do the products of hydrolysis of fMet peptides. The directed migration of cells in response to such peptides is probably brought about by the binding of the peptide to a cell receptor with subsequent cleavage by peptidase specific for aromatic residues, a process that allows the chemical gradient to be detected.
摘要
N-甲酰甲硫氨酰（fMet）肽作为吞噬细胞趋化剂的效力与其水解速率有关。此外，氯甲基酮和fMet肽的水解产物一样能抑制趋化作用。细胞对这类肽的定向迁移可能是由肽与细胞受体结合，随后被对芳香族残基具有特异性的肽酶裂解所引起的，这一过程使得化学梯度能够被检测到。
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本文引用的文献
1
Polymorphonuclear leukocyte chemotactic activity in rabbit serum and Guinea pig serum treated with immune complexes: evidence for c5a as the major chemotactic factor.
Infect Immun. 1970 Jun;1(6):521-5. doi: 10.1128/iai.1.6.521-525.1970.
2
A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.
Can J Biochem Physiol. 1959 Dec;37:1393-9.
3
Partial biochemical characterization of the activated esterase required in the complement-dependent chemotaxis of rabbit polymorphonuclear leukocytes.
J Exp Med. 1967 Jun 1;125(6):1021-30. doi: 10.1084/jem.125.6.1021.
4
Esterases of the polymorphonuclear leukocyte capable of hydrolyzing acetyl DL-phenyl-alanine beta-naphthyl ester. Relationship to the activatable esterase of chemotaxis.
J Exp Med. 1969 Mar 1;129(3):569-84. doi: 10.1084/jem.129.3.569.
5
Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes.
Proc Soc Exp Biol Med. 1969 May;131(1):203-7. doi: 10.3181/00379727-131-33840.
6
The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase.
J Exp Med. 1968 Apr 1;127(4):693-709. doi: 10.1084/jem.127.4.693.
7
Biochemical demonstration of the activatable esterase of the rabbit netrophil involved in the chemotactic response.
J Immunol. 1970 Nov;105(5):1057-67.
8
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin.
Biochim Biophys Acta. 1970 Dec 29;222(3):565-82. doi: 10.1016/0304-4165(70)90182-0.
9
Factors from saliva and oral bacteria, chemotactic for polymorphonuclear leukocytes: their possible role in gingival inflammation.
J Periodontol. 1970 Feb;41(2):71-80. doi: 10.1902/jop.1970.41.2.71.
10
Chemoreceptors in bacteria.
Science. 1969 Dec 26;166(3913):1588-97. doi: 10.1126/science.166.3913.1588.
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