注射非离子型造影剂前使用呋塞米或甘露醇对肾内氧张力的影响。

Effect of furosemide or mannitol before injection of a non-ionic contrast medium on intrarenal oxygen tension.

作者信息

Liss P, Nygren A, Ulfendahl H R, Erikson U

机构信息

Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.

出版信息

Adv Exp Med Biol. 1999;471:353-9. doi: 10.1007/978-1-4615-4717-4_42.

DOI:10.1007/978-1-4615-4717-4_42

PMID:10659166

Abstract

Oxygen tension (pO2) in rat renal cortex and outer medulla was studied after an intravenous injection of mannitol or furosemide, followed 10 minutes later by an intravenous injection of the non-ionic X-ray contrast medium (CM) iopromide (370 mg iodine/ml). Ten minutes after mannitol injection, before injection of CM, pO2 in the medulla had decreased from a control level of 32 +/- 3 to 28 +/- 4 mm Hg. The addition of CM caused a further decrease, to 24 +/- 5 mm Hg, which was a significant reduction. Ten minutes after furosemide injection the pO2 in the medulla had increased significantly, from a control value of 32 +/- 2 to 44 +/- 4 mm Hg. Injection of CM caused a significant decrease in pO2 to 37 +/- 3 mm. Ringer's solution (n = 6) caused no changes. We conclude that pretreatment with mannitol or furosemide does not prevent the CM-induced decrease in pO2 in the outer medulla.

摘要

在静脉注射甘露醇或呋塞米后，研究大鼠肾皮质和外髓质中的氧分压（pO2），10分钟后再静脉注射非离子型X射线造影剂（CM）碘普罗胺（370毫克碘/毫升）。注射甘露醇10分钟后，在注射CM之前，髓质中的pO2从对照水平的32±3毫米汞柱降至28±4毫米汞柱。添加CM导致进一步下降，至24±5毫米汞柱，这是显著降低。注射呋塞米10分钟后，髓质中的pO2显著升高，从对照值32±2毫米汞柱升至44±4毫米汞柱。注射CM导致pO2显著下降至37±3毫米汞柱。林格氏液（n = 6）未引起变化。我们得出结论，用甘露醇或呋塞米预处理并不能防止CM引起的外髓质pO2下降。