Tode T, Kikuchi Y, Hirata J, Kita T, Nakata H, Nagata I
Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Int J Gynaecol Obstet. 1999 Dec;67(3):169-74. doi: 10.1016/s0020-7292(99)00168-x.
To evaluate the degree of psychological dysfunction and levels of stress hormones in postmenopausal women with climacteric syndromes and effect of Korean red ginseng (RG) on them.
ACTH, cortisol and DHEA-S in peripheral blood from 12 postmenopausal women with climacteric syndromes or 8 postmenopausal women without any climacteric syndrome were measured before and 30 days after treatment with daily oral administration of 6 g RG. Blood samples were collected in the early morning on the bed-rest. In postmenopausal women with climacteric syndromes such as fatigue, insomnia and depression, psychological tests using the Cornell Medical Index (CMI) and the State-Trait Anxiety Inventory (STAI) were performed before and 30 days after treatment with RG.
CMI score as well as anxiety (A)-state in STAI score in postmenopausal women with climacteric syndromes was significantly higher than that without climacteric syndrome, while DHEA-S levels in postmenopausal women with climacteric syndromes were about a half of those without climacteric syndrome. Consequently, cortisol/DHEA-S (C/D) ratio was significantly higher in postmenopausal women with climacteric syndromes than in those without climacteric syndrome. When postmenopausal women with climacteric syndromes were treated with daily oral administration of 6 g RG for 30 days, CMI and STAI A-state scores decreased within normal range. Although the decreased DHEA-S levels were not restored to the levels in postmenopausal women without climacteric syndrome, the C/D ratio decreased significantly after treatment with RG.
Improvement of CMI and STAI scores in postmenopausal women suffering climacteric syndromes, particularly fatigue, insomnia and depression, by RG seemed to be brought about in part by effects of RG on stress-related hormones as shown by a decrease in C/D ratio.
评估患有更年期综合征的绝经后女性的心理功能障碍程度和应激激素水平，以及高丽参（RG）对其的影响。
对12名患有更年期综合征的绝经后女性或8名无任何更年期综合征的绝经后女性，在每日口服6克RG治疗前及治疗30天后，测量其外周血中的促肾上腺皮质激素（ACTH）、皮质醇和硫酸脱氢表雄酮（DHEA-S）。清晨卧床休息时采集血样。对患有疲劳、失眠和抑郁等更年期综合征的绝经后女性，在RG治疗前及治疗30天后，使用康奈尔医学指数（CMI）和状态-特质焦虑量表（STAI）进行心理测试。
患有更年期综合征的绝经后女性的CMI评分以及STAI评分中的焦虑（A）状态显著高于无更年期综合征的女性，而患有更年期综合征的绝经后女性的DHEA-S水平约为无更年期综合征女性的一半。因此,患有更年期综合征的绝经后女性的皮质醇/硫酸脱氢表雄酮（C/D）比值显著高于无更年期综合征的女性。当患有更年期综合征的绝经后女性每日口服6克RG治疗30天时，CMI和STAI A状态评分降至正常范围。虽然降低的DHEA-S水平未恢复到无更年期综合征的绝经后女性的水平，但RG治疗后C/D比值显著降低。
RG似乎部分通过降低C/D比值对与应激相关的激素产生影响，从而改善患有更年期综合征，尤其是疲劳、失眠和抑郁的绝经后女性的CMI和STAI评分。
