早产和分娩时孕妇血清白细胞介素1、2、6、8及白细胞介素-2受体水平

Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery.

作者信息

Alvarez-de-la-Rosa M, Rebollo F J, Codoceo R, Gonzalez Gonzalez A

机构信息

Department of Obstetrics and Gynecology, La Paz Hospital, Universidad Autónoma de Madrid, Spain.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2000 Jan;88(1):57-60. doi: 10.1016/s0301-2115(99)00129-3.

DOI:10.1016/s0301-2115(99)00129-3

PMID:10659917

Abstract

OBJECTIVE

To determine the concentrations of maternal serum interleukins (ILs) 1, 2, 6, 8 and IL-2 receptors (IL-2R) in patients in their second and third trimesters of pregnancy and in preterm labor and delivery without evidence of chorioamnionitis.

STUDY DESIGN

The study was conducted in La Paz Maternal Hospital, Madrid. Maternal serum IL concentrations were measured in 103 gravidas during preterm labor and delivery. The Mann-Whitney U test was used for analysis.

RESULTS

Women in preterm labor and delivery had significantly higher median IL-2R concentration. Women who responded to tocolysis had significantly lower serum concentrations of IL-6. IL-2R and IL-6 serum concentrations predict delivery in 48 h and before 34 weeks gestation.

CONCLUSIONS

Compared with non-laboring gravidas, those in idiopathic preterm labor or delivery had significantly higher concentrations of maternal serum IL-2R. Both IL-6 and IL-2R may predict failure of tocolysis. IL-2 does not seem to play an important role in pregnancy.

摘要