Moorthy R S, Valluri S
Indiana University School of Medicine, Indianapolis, USA.
Curr Opin Ophthalmol. 1999 Dec;10(6):438-46. doi: 10.1097/00055735-199912000-00012.
Systemic drug-induced ocular side effects are increasing because of the vast numbers of new drugs being introduced. Reports of drug-induced ocular toxicity must be well documented, and other causes of these side effects must be ruled out to help establish causality. We reviewed the most recent reports of the most commonly used and newest systemic drugs that have been implicated in ocular toxicity. Using toxicologic criteria needed to establish causality, data from reports of ocular toxicity associated with systemic cidofovir (Vistide), sildenafil (Viagra), vigabatrin (Sabril), tamoxifen (Nolvadex), hydroxychloroquine (Plaquenil)/chloroquine (Aralen), amiodarone (Cordarone), and lovastatin (Mevacor)/simvastatin (Zocor) were evaluated and summarized. The probability for causality was determined to be high for all these drugs except for vigabatrin and lovastatin/simvastatin. Methods for detecting, preventing, and treating ocular toxic reactions were then reviewed for each drug.
由于大量新药的问世，全身性药物引起的眼部副作用正在增加。药物性眼毒性的报告必须有充分的记录，并且必须排除这些副作用的其他原因以帮助确定因果关系。我们回顾了与眼毒性有关的最常用和最新全身性药物的最新报告。使用确定因果关系所需的毒理学标准，对与全身性西多福韦（Vistide）、西地那非（伟哥）、氨己烯酸（喜保宁）、他莫昔芬（诺瓦得士）、羟氯喹（帕罗喹）/氯喹（阿的平）、胺碘酮（可达龙）和洛伐他汀（美降脂）/辛伐他汀（舒降之）相关的眼毒性报告数据进行了评估和总结。除氨己烯酸和洛伐他汀/辛伐他汀外，所有这些药物的因果关系可能性均被确定为高。然后针对每种药物回顾了检测、预防和治疗眼毒性反应的方法。
