c-myc基因座是B型逆转录病毒诱导的T细胞淋巴瘤中常见的整合位点。
The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.
作者信息
Rajan L, Broussard D, Lozano M, Lee C G, Kozak C A, Dudley J P
机构信息
Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78705, USA.
出版信息
J Virol. 2000 Mar;74(5):2466-71. doi: 10.1128/jvi.74.5.2466-2471.2000.
Abstract
Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance.
摘要
B型致白血病病毒（TBLV）可诱发迅速出现的T细胞白血病。在检测的30个肿瘤中，有2个可检测到TBLV插入c-myc基因附近，而80%的肿瘤显示c-myc过表达。15号染色体上的TBLV插入（包括一个新发现的位点Pad7）可能通过远距离的顺式作用效应导致c-myc过表达。
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