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1
Membrane potential dependent binding of scorpion toxin to action potential Na+ ionophore.蝎毒素与动作电位钠离子载体的膜电位依赖性结合。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2682-6. doi: 10.1073/pnas.73.8.2682.
2
Interactions of neurotoxins with the action potential NA + ionophore.神经毒素与动作电位钠离子载体的相互作用。
J Supramol Struct. 1976;5(3):397-407. doi: 10.1002/jss.400050312.
3
Purification of a toxic protein from scorpion venom which activates the action potential Na+ ionophore.从蝎毒中纯化一种能激活动作电位钠离子载体的有毒蛋白质。
J Biol Chem. 1976 Sep 25;251(18):5528-36.
4
Cooperative activation of action potential Na+ ionophore by neurotoxins.神经毒素对动作电位钠离子载体的协同激活作用。
Proc Natl Acad Sci U S A. 1975 May;72(5):1782-6. doi: 10.1073/pnas.72.5.1782.
5
Binding to saxitoxin to electrically excitable neuroblastoma cells.与石房蛤毒素结合至电可兴奋神经母细胞瘤细胞。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):218-22. doi: 10.1073/pnas.75.1.218.
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Sea anemone toxin and scorpion toxin share a common receptor site associated with the action potential sodium ionophore.海葵毒素和蝎子毒素共享一个与动作电位钠离子载体相关的共同受体位点。
J Biol Chem. 1978 Oct 25;253(20):7393-6.
7
Membrane potential dependent binding of scorpion toxin to the action potential sodium ionophore. Studies with a 3-(4-hydroxy 3-[125I] iodophenyl) propionyl derivative.蝎毒素与动作电位钠离子载体的膜电位依赖性结合。用3-(4-羟基-3-[125I]碘苯基)丙酰衍生物进行的研究。
J Neurochem. 1978 Aug;31(2):397-407. doi: 10.1111/j.1471-4159.1978.tb02655.x.
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Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport.藜芦碱、蝎毒素和河豚毒素对膜电位及离子转运的影响表明，非兴奋性胶质瘤细胞中存在钠通道。
Pflugers Arch. 1983 Jun 1;397(4):260-4. doi: 10.1007/BF00580258.
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Isolation of a scorpion toxin for use as a probe of the electrically excitable sodium channel.分离一种用作电可兴奋钠通道探针的蝎毒素。
Biochem Biophys Res Commun. 1976 Sep 20;72(2):646-53. doi: 10.1016/s0006-291x(76)80089-7.
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Scorpion neurotoxin - a presynaptic toxin which affects both Na+ and K+ channels in axons.蝎神经毒素——一种影响轴突中钠通道和钾通道的突触前毒素。
Biochem Biophys Res Commun. 1975 May 5;64(1):115-21. doi: 10.1016/0006-291x(75)90226-0.

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Compound-specific effects of mutations at Val787 in DII-S6 of Nav 1.4 sodium channels on the action of sodium channel inhibitor insecticides.DII-S6 区 Nav1.4 钠通道中 Val787 突变对钠通道抑制剂类杀虫剂作用的化合物特异性影响。
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Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels.α-蝎毒素会损害一种构象变化，这种变化会导致肌肉钠通道快速失活。
J Gen Physiol. 2008 Aug;132(2):251-63. doi: 10.1085/jgp.200809995.
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The interpretation of current-clamp recordings in the cell-attached patch-clamp configuration.在细胞贴附式膜片钳配置下对电流钳记录的解读。
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Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivation.蝎毒素Ts3与钠通道的电压依赖性位移及其对失活控制的影响
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Membrane potential depolarization and increased intracellular pH accompany the acrosome reaction of sea urchin sperm.膜电位去极化和细胞内pH值升高伴随着海胆精子的顶体反应。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6066-70. doi: 10.1073/pnas.78.10.6066.
6
Tetrodotoxin interferes with the reaction of scorpion toxin (Buthus tamulus) at the sodium channel of the excitable membrane.河豚毒素干扰蝎毒素（巴勒斯坦黄蝎）在可兴奋膜钠通道上的反应。
Pflugers Arch. 1983 Jun 1;397(4):306-11. doi: 10.1007/BF00580266.
7
Na+-channel-associated scorpion toxin receptor sites as probes for neuronal evolution in vivo and in vitro.钠通道相关蝎毒素受体位点作为体内外神经元进化的探针。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1245-9. doi: 10.1073/pnas.78.2.1245.
8
Validation of the use of the lipophilic thiocyanate anion for the determination of membrane potential in Ehrlich ascites tumor cells.亲脂性硫氰酸根阴离子用于测定艾氏腹水瘤细胞膜电位的验证。
J Membr Biol. 1989 Feb;107(2):169-78. doi: 10.1007/BF01871722.
9
Gating of Na channels. Inactivation modifiers discriminate among models.钠通道的门控。失活修饰剂对模型进行区分。
J Gen Physiol. 1987 Feb;89(2):253-74. doi: 10.1085/jgp.89.2.253.
10
The purification of ion channels from excitable cells.从可兴奋细胞中纯化离子通道。
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本文引用的文献

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A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
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Separation of toxic components from the brazillian scorpion Tityus serrulatus venom.从巴西蝎子锯齿脂鲤毒液中分离有毒成分。
Mem Inst Butantan. 1966;33(3):899-902.
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[Effect of scorpion venom on ionic currents of the node of Ranvier. II. Incomplete sodium inactivation].[蝎毒对郎飞结离子电流的影响。II. 不完全钠失活]
Pflugers Arch. 1968;303(2):150-61. doi: 10.1007/BF00592632.
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Incomplete sodium inactivation in nodes of Ranvier treated with scorpion venom.用蝎毒处理的郎飞结中钠失活不完全。
Experientia. 1968 Jan 15;24(1):41-2. doi: 10.1007/BF02136780.
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Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus.动物神经毒素的纯化。从澳链尾蝎、北非杀人蝎和以色列金蝎毒液中分离并鉴定出11种神经毒素。
Eur J Biochem. 1970 Nov;16(3):514-23. doi: 10.1111/j.1432-1033.1970.tb01111.x.
6
Genes for neuronal properties expressed in neuroblastoma x L cell hybrids.在神经母细胞瘤x L细胞杂种中表达的神经元特性相关基因。
Proc Natl Acad Sci U S A. 1971 Jan;68(1):234-9. doi: 10.1073/pnas.68.1.234.
7
Neuronal tumor cells with excitable membranes grown in vitro.在体外培养的具有可兴奋膜的神经元肿瘤细胞。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1004-10. doi: 10.1073/pnas.64.3.1004.
8
Electrogenesis in mouse neuroblastoma cells in vitro.体外培养的小鼠神经母细胞瘤细胞的电发生
J Cell Physiol. 1971 Jun;77(3):337-52. doi: 10.1002/jcp.1040770308.
9
Ion transfer across lipid membranes in the presence of gramicidin A. I. Studies of the unit conductance channel.短杆菌肽A存在下离子跨脂质膜的转运。I. 单位电导通道的研究。
Biochim Biophys Acta. 1972 Aug 9;274(2):294-312. doi: 10.1016/0005-2736(72)90178-2.
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Binding of radioactive tetrodotoxin to nerve membrane preparations.放射性河豚毒素与神经膜制剂的结合
Biochim Biophys Acta. 1972 May 9;266(2):548-56. doi: 10.1016/0005-2736(72)90110-1.

蝎毒素与动作电位钠离子载体的膜电位依赖性结合。

Membrane potential dependent binding of scorpion toxin to action potential Na+ ionophore.

作者信息

Catterall W A, Ray R, Morrow C S

出版信息

Proc Natl Acad Sci U S A. 1976 Aug;73(8):2682-6. doi: 10.1073/pnas.73.8.2682.

DOI:10.1073/pnas.73.8.2682
PMID:1066680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430712/
Abstract

Depolarization of neuroblastoma cells causes a 70-fold increase in the apparent dissociation constant KD for scorpion toxin enhancement of activation of the action potential Na+ ionophore by veratridine and a large increase in the rate of reversal of scorpion toxin action. Depolarization also inhibits binding of 125I-labeled scorpion toxin to a small number of saturable binding sites on electrically excitable neuroblastoma cells and increases the rate of dissociation of scorpion toxin from these sites. The results suggest that scorpion toxin binds to a regulatory component of the action potential Na+ ionophore whose conformation changes on depolarization.

摘要

神经母细胞瘤细胞的去极化导致蝎毒素增强藜芦碱激活动作电位钠离子载体作用的表观解离常数KD增加70倍，且蝎毒素作用的逆转速率大幅提高。去极化还抑制125I标记的蝎毒素与电可兴奋神经母细胞瘤细胞上少量可饱和结合位点的结合，并增加蝎毒素从这些位点的解离速率。结果表明，蝎毒素与动作电位钠离子载体的一个调节成分结合，该成分的构象在去极化时发生变化。