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在神经母细胞瘤x L细胞杂种中表达的神经元特性相关基因。

Genes for neuronal properties expressed in neuroblastoma x L cell hybrids.

作者信息

Minna J, Nelson P, Peacock J, Glazer D, Nirenberg M

出版信息

Proc Natl Acad Sci U S A. 1971 Jan;68(1):234-9. doi: 10.1073/pnas.68.1.234.

DOI:10.1073/pnas.68.1.234
PMID:5276295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC391202/
Abstract

Neuroblastoma cells with electrically excitable membranes were fused with electrically passive L cells having a hitherto undescribed electrical marker. Hybrid cells, examined 10-40 generations after fusion, were found to be electrically excitable. The results show that at least a part of the genetic information for neuron differentiation can be functionally expressed in N x L hybrid cells. Evidence for the regulation of action potential components was also found.

摘要

具有电兴奋性膜的神经母细胞瘤细胞与具有一种迄今未描述的电标记的电惰性L细胞融合。在融合后10 - 40代检查的杂交细胞被发现具有电兴奋性。结果表明，至少部分神经元分化的遗传信息可以在N×L杂交细胞中功能性表达。还发现了动作电位成分受调控的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7e/391202/ef0cffaa9d10/pnas00076-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7e/391202/ef0cffaa9d10/pnas00076-0244-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7e/391202/ef0cffaa9d10/pnas00076-0244-a.jpg

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SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.体外成纤维细胞交配产生的杂种及其假定重组体的选择
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