Cimperman J, Maraspin V, Lotric-Furlan S, Ruzić-Sabljić E, Strle F
Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia.
Wien Klin Wochenschr. 1999 Dec 10;111(22-23):961-3.
Thirty-six patients with Lyme meningitis diagnosed at the Department of Infectious Diseases, University Medical Centre, Ljubljana in 1993 and 1994 were enrolled in a prospective study. All patients had lymphocytic meningitis, negative serum IgM antibody titres to tick-borne encephalitis virus and met at least one of the following four criteria: i) isolation of Borrelia burgdorferi sensu lato from cerebrospinal fluid (2 patients), ii) intrathecal borrelial antibody production (22 patients) iii) seroconversion to borrelial antigens (3 patients) and/or iv) erythema migrans in the period of four months prior to the onset of neurological involvement (21 patients). All patients underwent antibiotic treatment and were followed up for one year. The results of our study revealed that Lyme meningitis frequently occurs without meningeal signs and is often accompanied by additional neurological and/or other manifestations of Lyme borreliosis. During the first year after antibiotic treatment, minor and major manifestations of Lyme borreliosis persisted or occurred for the first time in several patients. They were not infrequent even at the examination performed one year after therapy.
1993年和1994年，卢布尔雅那大学医学中心传染病科诊断的36例莱姆病脑膜炎患者被纳入一项前瞻性研究。所有患者均患有淋巴细胞性脑膜炎，血清对蜱传脑炎病毒的IgM抗体滴度为阴性，且至少符合以下四项标准中的一项：i）从脑脊液中分离出伯氏疏螺旋体狭义种（2例患者），ii）鞘内产生伯氏疏螺旋体抗体（22例患者），iii）血清转化为伯氏疏螺旋体抗原（3例患者）和/或iv）在神经受累发作前四个月内出现游走性红斑（21例患者）。所有患者均接受了抗生素治疗，并随访了一年。我们的研究结果显示，莱姆病脑膜炎常无脑膜体征出现，且常伴有莱姆病的其他神经和/或其他表现。在抗生素治疗后的第一年，莱姆病的轻微和严重表现持续存在或在数名患者中首次出现。即使在治疗一年后的检查中，这些表现也并不罕见。
