Morimoto Y, Sugimoto T, Okada M, Mukai T
Department of Surgery, Kobe University School of Medicine, Japan.
Angiology. 2000 Jan;51(1):61-8. doi: 10.1177/000331970005100110.
The authors reviewed the clinical value of platelet scintigraphy by using autologous platelets labeled with indium-111-oxine to detect thrombotic activity at vascular thrombosis sites. Thirty-nine patients with deep vein thrombosis, 28 with arteriosclerosis obliterans, and 10 with pulmonary embolism were the subjects of this study. Platelet accumulation on scintigrams had a tendency to correlate with aggravation of acute thrombotic symptoms in deep vein thrombosis and arteriosclerosis obliterans. In addition, appropriate thrombolytic and anticoagulant therapy resulted in reduced platelet accumulation in conjunction with improvement of acute symptoms. On the other hand, this type of scintigraphy was not so sensitive for assessment of pulmonary embolism. Platelet scintigraphy could facilitate the assessment of thrombotic activity and might be useful for determining the optimal indication of thrombolytic and anticoagulant therapy for acute vascular thrombosis.
作者通过使用铟-111-氧喹啉标记的自体血小板来检测血管血栓形成部位的血栓活性，回顾了血小板闪烁扫描术的临床价值。本研究的对象为39例深静脉血栓形成患者、28例闭塞性动脉硬化患者和10例肺栓塞患者。闪烁扫描图上的血小板聚集倾向于与深静脉血栓形成和闭塞性动脉硬化中急性血栓症状的加重相关。此外，适当的溶栓和抗凝治疗会使血小板聚集减少，同时急性症状得到改善。另一方面，这种类型的闪烁扫描术对肺栓塞的评估不太敏感。血小板闪烁扫描术有助于评估血栓活性，可能有助于确定急性血管血栓形成的溶栓和抗凝治疗的最佳指征。
