白细胞募集与急性炎症反应。
Leukocyte recruitment and the acute inflammatory response.
作者信息
Kubes P, Ward P A
机构信息
Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Alberta, Canada.
出版信息
Brain Pathol. 2000 Jan;10(1):127-35. doi: 10.1111/j.1750-3639.2000.tb00249.x.
Abstract
Leukocyte recruitment is a hallmark feature of the inflammatory response. This review summarizes the generally accepted paradigm of leukocyte recruitment based on studies using intravital microscopy to visualize the microcirculation. The role of selectins and alpha4-integrin in rolling as well as integrin-mediated adhesion is discussed. However, it is becoming increasingly clear that the recruitment cascade within organs differs and therefore the review also attempts to highlight what is and is not known regarding leukocyte recruitment into the brain microvasculature. In the second part of this review, we provide some discussion of mechanisms by which the inflammatory response may be terminated. Particular emphasis on nuclear factor Nf kappaB and how IL10, IL13 and secreted leukocyte protease inhibitor (SLPI) may impact upon the Nf kappaB-dependent inflammatory response is presented.
摘要
白细胞募集是炎症反应的一个标志性特征。本综述基于利用活体显微镜观察微循环的研究，总结了目前普遍接受的白细胞募集模式。文中讨论了选择素和α4整合素在滚动以及整合素介导的黏附中的作用。然而，越来越清楚的是，各器官内的募集级联反应存在差异，因此本综述也试图强调关于白细胞募集进入脑微血管系统已知和未知的方面。在本综述的第二部分，我们对炎症反应可能终止的机制进行了一些讨论。特别强调了核因子NfκB，以及白细胞介素10、白细胞介素13和分泌型白细胞蛋白酶抑制剂（SLPI）如何可能影响依赖NfκB的炎症反应。
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本文引用的文献
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Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin.白细胞介素-4在体内诱导白细胞募集的分子机制：α4整合素的关键作用
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CD18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke.CD18介导的中性粒细胞募集参与了再灌注性卒中而非非再灌注性卒中的发病机制。
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