Buchino J J, Ciambarella E, Light I
Am J Dis Child. 1979 Mar;133(3):270-3. doi: 10.1001/archpedi.1979.02130030046007.
Thirteen cases of group D streptococcal neonatal sepsis and/or meningitis were identified at the Cincinnati Children's Hospital from 1970 to 1976. Ages at onset of disease ranged from 1 to 25 days. The most frequent symptoms were fever (five cases), lethargy (five cases), and respiratory difficulty (four cases). Blood cultures for seven infants were positive; CSF cultures for five infants were positive; and CSF and blood cultures for one infant were both positive. In 12 patients, parenteral antibiotic therapy consisted of a penicillin and an aminoglycoside. One infant with a severe meningomyelocele died. The other 12 infants showed a rapid clinical response with seven patients improving within 48 hours of the start of therapy. Infection with group D streptococcus results in a low-grade systemic disease in both full-term and premature infants that responds favorably to appropriate therapy.
1970年至1976年期间，辛辛那提儿童医院确诊了13例D组链球菌引起的新生儿败血症和/或脑膜炎。发病年龄在1至25天之间。最常见的症状是发热（5例）、嗜睡（5例）和呼吸困难（4例）。7名婴儿的血培养呈阳性；5名婴儿的脑脊液培养呈阳性；1名婴儿的脑脊液和血培养均呈阳性。12名患者接受了胃肠外抗生素治疗，治疗药物包括青霉素和氨基糖苷类药物。1名患有严重脊髓脊膜膨出的婴儿死亡。其他12名婴儿临床反应迅速，7名患者在治疗开始后48小时内病情好转。D组链球菌感染在足月儿和早产儿中都会引发轻度全身性疾病，适当治疗后反应良好。
