Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu M A, Saito T
Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan.
Biochim Biophys Acta. 1999 Dec 23;1489(2-3):421-7. doi: 10.1016/s0167-4781(99)00190-6.
The RING finger (C3HC4-type zinc finger) is a variant zinc finger motif presents in a new family of proteins. A new member of the RING finger family was identified and its cDNA structures were determined in human and mouse. The predicted protein consisting of a 144 amino acid residues is very conservative between the two species and contains a canonical RING-H2 finger motif (C3H2C2) at the carboxyl-terminal region. The genes were designated as RNF11/Rnf11 for RING finger protein 11. A single 2.4-kb transcript of mouse Rnf11 was ubiquitously expressed in various fetal and adult mouse tissues by the Northern blot analysis. The human RNF11 gene was mapped on chromosome 1p31-p32 region, where frequent alterations have been observed in T-cell acute lymphoblastic leukemia.
环状结构域（C3HC4型锌指结构）是一种存在于新的蛋白质家族中的变异锌指基序。鉴定出了环状结构域家族的一个新成员，并确定了其在人和小鼠中的cDNA结构。预测该蛋白质由144个氨基酸残基组成，在这两个物种之间非常保守，并且在羧基末端区域含有一个典型的RING-H2指基序（C3H2C2）。这些基因被命名为RNF11/Rnf11，表示环状结构域蛋白11。通过Northern印迹分析，小鼠Rnf11的单一2.4kb转录本在各种胎儿和成年小鼠组织中广泛表达。人类RNF11基因定位于染色体1p31-p32区域，在T细胞急性淋巴细胞白血病中经常观察到该区域的改变。
