异基因外周血细胞移植治疗伴有骨髓纤维化的高嗜酸性粒细胞综合征

Allogeneic peripheral blood cell transplantation for hypereosinophilic syndrome with myelofibrosis.

作者信息

Vazquez L, Caballero D, Cañizo C D, Lopez C, Hernandez R, Gonzalez I, Flores T, San Miguel J F

机构信息

Hematology Service, University Hospital of Salamanca; and Centro de Investigación del Cancer (CIC), University of Salamanca, CSIC, Spain.

出版信息

Bone Marrow Transplant. 2000 Jan;25(2):217-8. doi: 10.1038/sj.bmt.1702102.

DOI:10.1038/sj.bmt.1702102

PMID:10673685

Abstract

Patients with hypereosinophilic syndrome (HES) display a very heterogeneous clinical picture ranging from asymptomatic cases to very aggressive forms. We report a 38-year-old woman with progressive HES who developed severe myelofibrosis and was treated by allogeneic stem cell transplantation, using peripheral blood (PBSCT) instead of bone marrow as the source of progenitor cells, after conditioning with cytoxan and busulphan. To the best of our knowledge, this is the first case of HES with myelofibrosis treated with PBSCT. The patient remains alive 8 months post-PBSCT, and bone marrow fibrosis has significantly decreased following transplantation. Bone Marrow Transplantation (2000) 25, 217-218.

摘要

高嗜酸性粒细胞综合征（HES）患者的临床表现非常多样，从无症状病例到极具侵袭性的类型都有。我们报告了一名38岁患有进行性HES的女性，她发展为严重骨髓纤维化，并在接受环磷酰胺和白消安预处理后，采用外周血作为祖细胞来源进行异基因干细胞移植（PBSCT）而非骨髓移植进行治疗。据我们所知，这是首例采用PBSCT治疗的伴有骨髓纤维化的HES病例。该患者在PBSCT后8个月仍然存活，移植后骨髓纤维化显著减轻。《骨髓移植》（2000年）第25卷，第217 - 218页。