Sadoun A, Lacotte L, Delwail V, Randriamalala E, Patri S, Babin P, Brizard A, Guilhot F
Département d'Hématologie et Oncologie Médicale, CHU La Milétrie, Poitiers, France.
Bone Marrow Transplant. 1997 Apr;19(7):741-3. doi: 10.1038/sj.bmt.1700729.
A 33-year-old man with an atypical course of hypereosinophilic syndrome including malignant hypercalcemia, osteolytic lesions and evolution into severe myelofibrosis was treated by allogeneic bone marrow transplantation after conditioning with cytoxan and total body irradiation. As the transplant was sex-mismatched, chimerism was studied by means of cytogenetic analysis and Y chromosomal DNA amplification by PCR assay. Long-term complete remission has been assessed by normalization of blood cell counts, magnetic resonance imaging and karyotypic analysis. A relapse was observed 40 months after transplantation. The patient remains alive 44 months post-BMT. This case report is compared with those reported in the literature.
一名33岁男性患有不典型的嗜酸性粒细胞增多综合征，包括恶性高钙血症、溶骨性病变并进展为严重骨髓纤维化，在接受环磷酰胺和全身照射预处理后接受了异基因骨髓移植。由于移植存在性别不匹配，通过细胞遗传学分析和PCR法进行Y染色体DNA扩增来研究嵌合现象。通过血细胞计数正常化、磁共振成像和核型分析评估长期完全缓解情况。移植后40个月观察到复发。患者在骨髓移植后44个月仍然存活。本病例报告与文献报道的病例进行了比较。
