Ager P, Samala E, Bosworth J, Rubin M, Ghossein N A
Am J Surg. 1979 Feb;137(2):228-30. doi: 10.1016/0002-9610(79)90151-x.
Thirteen patients with an anal or rectal carcinoma were given curative radiotherapy. Four had medically inoperable tumors, one had a surgically inoperable tumor and eight refused abdominoperineal resection. Six patients received external radiotherapy only. Seven patients received external radiotherapy and an interstitial implant. Nine of thirteen patients (60 per cent) are alive without evidence of disease from fifteen to fifty-five months (average, 30 months). Six of seven patients who received external radiotherapy combined with an interstitial implant were controlled locally, whereas three of six patients who received external radiotherapy only were controlled. Patients who underwent total excision and/or fulguration prior to irradiation had better local control than those who underwent either biopsy only or a subtotal excision. This treatment method may be offered as an alternative to abdominoperineal resection in patients who are medically unfit or who refuse surgery.
13例肛管或直肠癌患者接受了根治性放疗。4例患者的肿瘤因医学原因无法手术切除，1例患者的肿瘤因手术原因无法切除，8例患者拒绝腹会阴联合切除术。6例患者仅接受了外照射放疗。7例患者接受了外照射放疗并进行了组织间插植。13例患者中有9例（60%）存活，从15个月到55个月无疾病证据（平均30个月）。7例接受外照射放疗联合组织间插植的患者中有6例局部得到控制，而仅接受外照射放疗的6例患者中有3例得到控制。在放疗前接受了全切除和/或电灼术的患者比仅接受活检或次全切除的患者有更好的局部控制。对于因医学原因不适合手术或拒绝手术的患者，这种治疗方法可作为腹会阴联合切除术的替代方案。
