Afrasiabi M A, Vaziri N D, Gwinup G, Mays D M, Barton C H, Ness R L, Valenta L J
Ann Intern Med. 1979 Mar;90(3):335-8. doi: 10.7326/0003-4819-90-3-335.
Total serum and urinary thyroxine (T4), triiodothyronine (T3), and thyroxine-binding globulin (TBG) as well as serum free T4, thyroid-stimulating hormone (TSH), and T3 resin uptake (T3RU) were measured in seven patients with the nephrotic syndrome. The nephrotic syndrome was defined by proteinuria exceeding 3 g/24 h. All patients were clinically euthyroid. Most values for total serum T4, free T4, T3, T3RU, TBG, and TSH were within normal limits. However, the mean serum T3 and TBG values were significantly lower in patients compared with the control group. The values (mean +/- 2 SD) for urinary T4 were 24.3 +/- 20.3 in the patient group and 1.5 +/- 0.7 microgram/24 h in the control group. Urinary T3 values for patients and the control group were 2100 +/- 856 and 848 +/- 253 ng/24 h respectively. Urinary TBG was 2.1 +/- 1.8 mg/24 h in the patients and undetectable in the control group. There was no correlation between daily urinary T3 and T4 and urinary TBG. There was a weak correlation between daily urinary protein excretion and urinary T4 (r = 0.5).
对7例肾病综合征患者测定了血清和尿中的总甲状腺素（T4）、三碘甲状腺原氨酸（T3）、甲状腺素结合球蛋白（TBG），以及血清游离T4、促甲状腺激素（TSH）和T3树脂摄取率（T3RU）。肾病综合征的定义为蛋白尿超过3g/24小时。所有患者临床甲状腺功能均正常。血清总T4、游离T4、T3、T3RU、TBG和TSH的大多数值均在正常范围内。然而，与对照组相比，患者的血清T3和TBG平均值显著降低。患者组尿T4值（均值±2标准差）为24.3±20.3，对照组为1.5±0.7μg/24小时。患者组和对照组的尿T3值分别为2100±856和848±253ng/24小时。患者尿TBG为2.1±1.8mg/24小时，对照组未检测到。每日尿T3和T4与尿TBG之间无相关性。每日尿蛋白排泄量与尿T4之间存在弱相关性（r = 0.5）。
