脊髓小脑共济失调3型/马查多-约瑟夫病患者的聚散功能障碍：同视机研究

Vergence disorders in patients with spinocerebellar ataxia 3/Machado-Joseph disease: a synoptophore study.

作者信息

Ohyagi Y, Yamada T, Okayama A, Sakae N, Yamasaki T, Ohshima T, Sakamoto T, Fujii N, Kira J

机构信息

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

出版信息

J Neurol Sci. 2000 Feb 15;173(2):120-3. doi: 10.1016/s0022-510x(99)00309-3.

DOI:10.1016/s0022-510x(99)00309-3

PMID:10675655

Abstract

Diplopia, a common symptom in spinocerebellar ataxia 3/Machado-Joseph disease (SCA3/MJD) cases, is not always due to asymmetric ophthalmoplegia. We found a Japanese SCA3/MJD family, in which three patients clearly had an impairment of divergence eye movement. We thus quantitatively examined the vergence ranges in eight Japanese SCA3/MJD cases using the synoptophore test. An impairment of the vergence eye movements was found in all patients, and the vergence impairment pattern, but not the ophthalmoplegia pattern, was found to be compatible with the diplopia pattern. The diplopia in SCA3/MJD cases is, therefore, attributed, at least in part, to the impairment of the vergence eye movements.

摘要

复视是脊髓小脑共济失调3型/马查多-约瑟夫病（SCA3/MJD）患者的常见症状，但并不总是由不对称性眼肌麻痹引起。我们发现一个日本SCA3/MJD家族，其中三名患者明显存在散开性眼球运动障碍。因此，我们使用同视机检查定量检测了8例日本SCA3/MJD患者的聚散范围。所有患者均存在聚散性眼球运动障碍，且发现聚散障碍模式而非眼肌麻痹模式与复视模式相符。因此，SCA3/MJD患者的复视至少部分归因于聚散性眼球运动障碍。