Amory J K, Bremner W J
Population Center for Research in Reproduction, Department of Veterans Affairs, Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, WA 98195-6420, USA.
Trends Endocrinol Metab. 2000 Mar;11(2):61-6. doi: 10.1016/s1043-2760(99)00224-6.
Efforts to create a hormonal contraceptive for men use testosterone to suppress the production of pituitary gonadotropins and, hence, spermatogenesis. However, conventional testosterone must be administered by frequent injection, and when given alone, is not 100% effective. Therefore, newer androgens and agents that synergistically suppress gonadotropin production are being studied to create an effective and commercially viable contraceptive.
研发男性荷尔蒙避孕药的努力是利用睾酮来抑制垂体促性腺激素的产生，从而抑制精子发生。然而，传统的睾酮必须频繁注射给药，而且单独使用时并非100%有效。因此，正在研究新型雄激素以及能协同抑制促性腺激素产生的药物，以研发出一种有效且具有商业可行性的避孕药。
