Ellis S, Mellor H
Dept of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK.
Trends Cell Biol. 2000 Mar;10(3):85-8. doi: 10.1016/s0962-8924(99)01710-9.
Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signalling proteins is intimately involved in endocytic traffic, providing novel insights into the control mechanisms that govern this process.
内吞作用是一个复杂但高效的过程,涉及从小分子到活化的信号受体再到整个微生物等各种货物的摄取和加工。人们对内吞途径的调控了解甚少。最近的证据表明,Rho GTPase信号蛋白家族密切参与内吞运输,为控制这一过程的机制提供了新的见解。