Rho GTPases 在神经胶质瘤细胞迁移和侵袭中的作用。
The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells.
机构信息
Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut-, Lebanon.
出版信息
Anal Cell Pathol (Amst). 2020 Jan 31;2020:9274016. doi: 10.1155/2020/9274016. eCollection 2020.
Abstract
Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells. In this review, we describe the role played by the Rho family of GTPases in the regulation of the invasion and migration of glioblastoma cells. Specifically, we focus on the role played by RhoA, Rac1, RhoG, and Cdc42 in cell migration through rearrangement of actin cytoskeleton, cell adhesion, and invasion. Finally, we highlight the importance of potentially targeting Rho GTPases in the treatment of glioblastoma.
摘要
星形细胞瘤是起源于星形胶质细胞的原发性恶性脑肿瘤。IV 级星形细胞瘤或胶质母细胞瘤是一种高度侵袭性肿瘤，发生在脑实质内。Rho 家族的小 GTPases，包括 Rac1、Cdc42 和 RhoA，是一个重要的家族，其成员是调节胶质母细胞瘤细胞侵袭和迁移的关键调节剂。在这篇综述中，我们描述了 Rho 家族 GTPases 在调节胶质母细胞瘤细胞侵袭和迁移中的作用。具体来说，我们重点介绍 RhoA、Rac1、RhoG 和 Cdc42 在通过肌动蛋白细胞骨架重排、细胞黏附和侵袭调节细胞迁移中的作用。最后，我们强调了靶向 Rho GTPases 在胶质母细胞瘤治疗中的重要性。
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