Sarmani S B, Abugassa I, Hamzah A, Yahya M D
Department of Nuclear Science, Universiti Kebangsaan Malaysia, Bangi, Malaysia.
Biol Trace Elem Res. 1999 Winter;71-72:365-76. doi: 10.1007/BF02784224.
Medicinal herb preparations prescribed for specific treatment purposes were purchased from markets and were analyzed by instrumental neutron activation analysis with k0 standardization. Then, 500-700 mg of each sample was pelletized under a pressure of six tones and irradiated together with monitors for alpha and neutron flux ratio determinations for about 6 h in a thermal flux of 2.29 x 10(12) n/cm2/s. The accuracy of the method was established by analyzing standard reference materials. Twenty-nine elements, Ag, As, Au, Ba, Br, Ca, Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Mn, Mo, Na, Rb, Sb, Sc, Se, Sm, Sr, Th, U, Yb, and Zn, were measured in all the samples, and Hg was detected in some samples, with good accuracy and reproducibility. The concentration of elements determined was found to vary depending on the composition of the herbs used. Although the trend linking the element of the medicinal plants to its curative abilities could not be clearly determined, this study showed that the toxic elements found in the samples were below the levels prescribed by health regulations. Nevertheless, such data are important to understand the pharmacological action and the exact mechanisms of action and formation of active constituents for each medicinal plant and to decide the dosage of the herbs used in the final formulation.
用于特定治疗目的的草药制剂从市场购买，并通过k0标准化的仪器中子活化分析进行分析。然后，将每个样品500-700毫克在6吨压力下压制成丸，并与监测器一起辐照，以测定α和中子通量比，在热通量为2.29×10(12) n/cm2/s的条件下辐照约6小时。通过分析标准参考物质确定了该方法的准确性。在所有样品中测量了29种元素，即银、砷、金、钡、溴、钙、铈、钴、铬、铯、铕、铁、铪、钾、镧、锰、钼、钠、铷、锑、钪、硒、钐、锶、钍、铀、镱和锌，在一些样品中检测到了汞，具有良好的准确性和重现性。所测定元素的浓度因所用草药的成分而异。虽然无法明确确定药用植物的元素与其治疗能力之间的联系趋势，但这项研究表明，样品中发现的有毒元素低于健康法规规定的水平。然而，这些数据对于理解每种药用植物的药理作用、活性成分的确切作用机制和形成以及确定最终制剂中所用草药的剂量非常重要。
