Lechner K, Geissler K, Jäger U, Greinix H, Kalhs P
Department of Internal Medicine, University of Vienna, Austria.
Ann Oncol. 1999;10 Suppl 6:45-51.
Leukemic cells are highly sensitive to chemotherapeutic agents. A reduction of the leukemic burden is easily achieved by chemotherapy in most cases. However, it is difficult to reduce the number of leukemic cells to such an extent that a regrowth does not occur and the patient is cured. Traditionally the therapy of acute leukemia is divided into induction and post remission therapy. The aim of the induction therapy is to reduce the number of leukemic cells to a morphologically undetectable level allowing normal hemopoiesis to recover. The goal of the post remission treatment is a further reduction of leukemic cells to zero or to very low levels which can be controlled by (still unknown) endogenous mechanisms. In some recent treatment protocols induction and the early part of post remission treatment are not strictly separated.
白血病细胞对化疗药物高度敏感。在大多数情况下，通过化疗很容易实现白血病负担的减轻。然而，将白血病细胞数量减少到不再复发且患者得以治愈的程度却很困难。传统上，急性白血病的治疗分为诱导缓解治疗和缓解后治疗。诱导缓解治疗的目的是将白血病细胞数量减少到形态学上无法检测的水平，以使正常造血功能得以恢复。缓解后治疗的目标是将白血病细胞进一步减少至零或极低水平，这可以通过（尚不清楚的）内源性机制来控制。在一些近期的治疗方案中，诱导缓解治疗和缓解后治疗的早期阶段并未严格区分。
