Wictorin L, Anneroth G, Frithiof L
Acta Odontol Scand. 1975;33(5):299-311. doi: 10.3109/00016357509004635.
The present study includes a reexamination of 10 patients who, two years ago received complete upper and lower denture treatment to eliminate an existing denture stomatitis. Clinical healing of the denture stomatitis was obtained only in one patient, whereas the remaining nine patients wtill displayed an obvious denture stomatitis. Biopsies were taken from the palatal mucosa and examined histologically, microradiographically, and by electron microscopy. The results of these examination indicated that, in denture stomatitis there is a reduced thickness of the epithelium, an absence of a stratum corneum, a markedly widened intercellular space, especially in the stratum basale, and an intense infiltration of inflammatory cells, plasma cells and lymphocytes in the connective tissue, as well as in the epithelium. These changes are characteristic features of an inflammatory process, and similar to the changes which occur, for example, in chronic, marginal gingivitis. The composition of the inflammatory infiltrate suggested that, in denture stomatitis, immunological phenomena influence the pattern of the tissue reaction.
本研究包括对10例患者的复查，这些患者在两年前接受了全口义齿治疗以消除现有的义齿性口炎。仅1例患者的义齿性口炎实现了临床治愈，而其余9例患者仍表现出明显的义齿性口炎。从腭黏膜取活检组织，并进行组织学、显微放射学及电子显微镜检查。这些检查结果表明，在义齿性口炎中，上皮厚度变薄，无角质层，细胞间间隙明显增宽，尤其是在基底层，结缔组织以及上皮中有炎性细胞、浆细胞和淋巴细胞的密集浸润。这些变化是炎症过程的特征性表现，类似于例如慢性边缘性牙龈炎中发生的变化。炎性浸润的组成表明，在义齿性口炎中，免疫现象影响组织反应模式。
