使用加速氦离子时相对生物有效性随肿瘤大小的变化

Variation of the relative biologic effectiveness with tumor size using accelerated helium ions.

作者信息

Shaeffer J, El-Mahdi A M, Aceto H, Constable W C

出版信息

Acta Radiol Ther Phys Biol. 1976 Jun;15(3):233-40. doi: 10.3109/02841867609131960.

DOI:10.3109/02841867609131960

Abstract

The RBE of an accelerated helium ion beam was determined on murine osteosarcomas ranging in size from single cells to visibly detectable lung colonies of approximately 1 X 10(-2) mm3. That the RBE increased as tumor size increased provides some biologic basis for the selection of advanced cases of neoplasia for clinical trials using relatively high LET radiation sources.

摘要

在大小从单细胞到明显可检测的约1×10⁻²立方毫米肺转移瘤的小鼠骨肉瘤上测定了加速氦离子束的相对生物效应（RBE）。RBE随着肿瘤大小增加而增加，这为使用相对高传能线密度（LET）辐射源的临床试验选择晚期肿瘤病例提供了一些生物学依据。