Sun T, Xu S, Huang H
Department of Orthopedic, Beijing Army General Hospital.
Zhonghua Wai Ke Za Zhi. 1997 Dec;35(12):735-7.
We compared methylprednisolone (MP), surgical decompression and both in acute cervical spinal cord injury without fracture and dislocation. The study involved 32 acute cervical spinal cord injury without fracture and dislocation. MP was given to 8 cases (high-MP group) within 8 hours after injury. 12 cases (surgical group) underwent surgical decompression (anterior or posterior approach) within 48 hours after injury. 12 cases (combined group) were treated with MP within 8 hour of their injury and surgical decompression within 48 hours after injury. Neurological function was assessed using scores according to international standards for neurological and functional classification of spinal cord injury. The results showed that combined group were more effective than high-MP or surgical group, in the complete or incomplete spinal cord injury, and in motor and sensory. The risk of such complication as gastrointestinal bleeding or delayed wound healing is not significant with using high-MP.
我们比较了甲基强的松龙（MP）、手术减压以及两者联合应用于无骨折脱位的急性颈髓损伤的疗效。该研究纳入了32例无骨折脱位的急性颈髓损伤患者。8例患者（高剂量MP组）在受伤后8小时内给予MP治疗。12例患者（手术组）在受伤后48小时内接受了手术减压（前路或后路手术）。12例患者（联合治疗组）在受伤后8小时内给予MP治疗，并在受伤后48小时内接受手术减压。根据脊髓损伤神经和功能分类的国际标准，使用评分对神经功能进行评估。结果显示，在完全性或不完全性脊髓损伤以及运动和感觉功能方面，联合治疗组比高剂量MP组或手术组更有效。使用高剂量MP时，胃肠道出血或伤口愈合延迟等并发症的风险并不显著。
