Sébédio J L, Gnaedig S, Chardigny J M
Institut National de la Recherche Agronomique, Unite de Nutrition Lipidique, Dijon, France.
Curr Opin Clin Nutr Metab Care. 1999 Nov;2(6):499-506. doi: 10.1097/00075197-199911000-00012.
New results on the physiological properties of conjugated linoleic acid have been published by several working groups, especially showing the effects of single conjugated linoleic acid isomers on carcinogenesis and body composition. Recently, other studies have shown that conjugated linoleic acid has an influence on diabetes mellitus, platelet aggregation and the immune system. Conjugated linoleic acid was found to modify prostaglandin metabolism and delta9-desaturase activity and influence apoptosis. Furthermore, improved analytical methods using 13C nuclear magnetic resonance and silver ion high performance liquid chromatography are available to investigate the composition of conjugated linoleic acid mixtures and the exact structure of separated isomers. Also, the synthesis of isolated isomers is described, as published by different authors, in order to determine further the effects of each single conjugated linoleic acid isomer. In addition, new data on the contents of conjugated linoleic acid in foods, human adipose tissue and fluids are given in this review. More data need to be obtained using isolated isomers, with particular emphasis on studies in humans.
多个研究小组发表了关于共轭亚油酸生理特性的新成果，特别展示了单一共轭亚油酸异构体对致癌作用和身体组成的影响。最近，其他研究表明共轭亚油酸对糖尿病、血小板聚集和免疫系统有影响。人们发现共轭亚油酸会改变前列腺素代谢和Δ9-去饱和酶活性，并影响细胞凋亡。此外，利用13C核磁共振和银离子高效液相色谱的改进分析方法可用于研究共轭亚油酸混合物的组成以及分离出的异构体的确切结构。不同作者还描述了分离异构体的合成方法，以便进一步确定每种单一共轭亚油酸异构体的作用。此外，本综述给出了食物、人体脂肪组织和体液中共轭亚油酸含量的新数据。需要使用分离出的异构体获取更多数据，尤其要侧重于人体研究。
