Gerisch G, Weber I
Max-Planck-Institut für Biochemie, Martinsried, D-82152, Germany.
Curr Opin Cell Biol. 2000 Feb;12(1):126-32. doi: 10.1016/s0955-0674(99)00066-6.
The ability of substrate-anchored Dictyostelium cells to divide without myosin II has opened the possibility of analysing the formation of cleavage furrows in the absence of a contractile ring made of filamentous myosin and actin. Similar possibilities exist in mutants of budding yeast and, less strictly, also in drug-treated mammalian cells. Myosin-II-independent activities in Dictyostelium include the microtubule-induced programming of the cell surface into ruffling areas and regions that are converted into a concave furrow, as well as the translocation of cortexillins and cross-linked membrane proteins towards the cleavage furrow. A centripetal flow of actin filaments followed by their disassembly in the cleavage furrow is proposed to underlie the translocation.
底物锚定的盘基网柄菌细胞在没有肌球蛋白II的情况下进行分裂的能力，开启了在没有由丝状肌球蛋白和肌动蛋白构成的收缩环的情况下分析分裂沟形成的可能性。在出芽酵母的突变体中也存在类似的可能性，在药物处理的哺乳动物细胞中这种可能性稍弱一些。盘基网柄菌中不依赖肌球蛋白II的活动包括微管诱导的细胞表面编程，使其形成褶皱区域以及转化为凹沟的区域，还有皮层蛋白和交联膜蛋白向分裂沟的转运。有人提出，肌动蛋白丝向心流动，随后在分裂沟中解体，是这种转运的基础。
