Karow J K, Wu L, Hickson I D
Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Curr Opin Genet Dev. 2000 Feb;10(1):32-8. doi: 10.1016/s0959-437x(99)00039-8.
The RecQ family of DNA helicases includes at least three members in humans that are defective in genetic disorders associated with cancer predisposition and/or premature aging. Recent studies have shed light on the roles of RecQ helicases in suppressing 'promiscuous' genetic recombination and in ensuring accurate chromosome segregation. In particular, the biochemical properties of several family members have been characterised and functional interactions with other nuclear proteins have been defined.
DNA解旋酶RecQ家族在人类中至少包括三个成员，它们在与癌症易感性和/或早衰相关的遗传疾病中存在缺陷。最近的研究揭示了RecQ解旋酶在抑制“杂乱”基因重组和确保准确染色体分离中的作用。特别是，已经对几个家族成员的生化特性进行了表征，并确定了它们与其他核蛋白的功能相互作用。
