白细胞介素-18在天然免疫中的作用。
The role of IL-18 in innate immunity.
作者信息
Akira S
机构信息
Department of Host Defense, CREST of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan.
出版信息
Curr Opin Immunol. 2000 Feb;12(1):59-63. doi: 10.1016/s0952-7915(99)00051-5.
IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response.
白细胞介素-18——一种具有强大诱导γ干扰素活性的新型细胞因子——在与白细胞介素-12协同作用的Th1介导的免疫反应中发挥重要作用。白细胞介素-18是白细胞介素-1家族的成员。白细胞介素-18受体系统及其信号转导途径与白细胞介素-1受体的相似。缺乏白细胞介素-18的小鼠已证明其在自然杀伤细胞活性和体内Th1反应中的关键作用。
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