Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Front Immunol. 2023 Jan 18;14:955369. doi: 10.3389/fimmu.2023.955369. eCollection 2023.
Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 , regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target.
白细胞介素（IL）-18 是一种干扰素-γ诱导物，属于多效性促炎因子的 IL-1 家族，IL-18 结合蛋白（IL-18BP）是 IL-18 的天然拮抗剂，调节其活性。此外，IL-18 在宿主固有和适应性免疫中发挥重要作用，IL-18BP 可在多种细胞中升高干扰素-γ水平，表明 IL-18BP 是 IL-18 介导免疫的负反馈抑制剂。与 IL-1β 类似，IL-18 细胞因子作为无活性前体产生，需要半胱天冬酶-1进一步加工成活性细胞因子，并通过 MyD88 介导下游信号通路。IL-18 被认为在人类炎症性皮肤病如银屑病、特应性皮炎、酒渣鼻和大疱性类天疱疮中发挥作用。目前，IL-18BP 在治疗炎症性皮肤病方面的研究较少，而 IL-18BP 正在其他疾病的临床试验中进行测试。因此，IL-18BP 是一个有前景的治疗靶点。
