Blanquet S, Mechulam Y, Schmitt E
Laboratoire de Biochimie, UMR 7654, Ecole Polytechnique-CNRS, Palaiseau cedex, F-91128, France.
Curr Opin Struct Biol. 2000 Feb;10(1):95-101. doi: 10.1016/s0959-440x(99)00055-x.
Subsequent to their aminoacylation, tRNAs are subject to specific maturation and/or correction processes. Aminoacylated tRNAs ready for use in translation are then specifically channelled to the ribosomal A or P sites. Structural and biochemical studies have opened the way towards furthering our understanding of these routes to the ribosome, which involve a strict distinction between initiator and elongator tRNAs.
在它们进行氨酰化之后，转运RNA（tRNA）会经历特定的成熟和/或校正过程。准备用于翻译的氨酰化tRNA随后会被特异性地引导至核糖体的A位点或P位点。结构和生化研究为进一步理解这些通向核糖体的途径开辟了道路，这些途径涉及起始tRNA和延伸tRNA之间的严格区分。
