Gajiwala K S, Burley S K
Laboratories of Molecular Biophysics, The Rockefeller University, New York, NY 10021, USA.
Curr Opin Struct Biol. 2000 Feb;10(1):110-6. doi: 10.1016/s0959-440x(99)00057-3.
The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of topologically related proteins with diverse biological functions have been characterized by X-ray crystallography and solution NMR spectroscopy. Recently, a winged helix transcription factor (RFX1) was shown to bind DNA using unprecedented interactions between one of its eponymous wings and the major groove. This surprising observation suggests that the winged helix proteins can be subdivided into at least two classes with radically different modes of DNA recognition.
翼状螺旋蛋白在大量螺旋-转角-螺旋蛋白中构成一个亚家族。自1993年发现翼状螺旋/叉头基序以来，大量具有不同生物学功能且拓扑结构相关的蛋白质已通过X射线晶体学和溶液核磁共振光谱进行了表征。最近，一种翼状螺旋转录因子（RFX1）被证明利用其同名翼之一与大沟之间前所未有的相互作用来结合DNA。这一惊人的发现表明，翼状螺旋蛋白可至少分为两类，它们具有截然不同的DNA识别模式。
