Longo F, Hebuterne X, Tran A, Staccini P, Hastier P, Schneider S, Benzaken S, Tirtaine C, Rampal P
Fédération des Maladies de l'Appareil Digestif, Hôpital de l'Archet II, CHU, Nice.
Gastroenterol Clin Biol. 2000 Jan;24(1):77-81.
To estimate the prevalence of viral hepatitis C markers and to determine independent risk factors in a population of patients with inflammatory bowel disease.
We studied 117 consecutive out-patients (male/female, 53/64; mean age 41 +/- 16 yrs) with ulcerative colitis (43 patients) or Crohn's disease (74 patients). Anti-hepatitis C virus antibodies were tested with a third generation Elisa test. The following risk factors were tested for each patient: duration of inflammatory bowel disease, number of colonoscopies, history of surgical procedures, blood transfusions, intravenous drug abuse and immunosuppressive treatments.
The seroprevalence of hepatitis C virus was 5.98% (7/117). The only risk factor independently associated with serological markers for hepatitis C virus was blood transfusion (odds ratio: 7.77; confidence interval: 95% (1.63-49.09); P=0.012).
The prevalence of hepatitis C virus infection was high in patients with inflammatory bowel disease, mainly due to blood transfusions. Colonoscopies and surgical procedures were not found to be additional risk factors for infection with hepatitis C virus.
评估丙型病毒性肝炎标志物的患病率，并确定炎症性肠病患者群体中的独立危险因素。
我们研究了117例连续性门诊患者（男/女，53/64；平均年龄41±16岁），其中溃疡性结肠炎患者43例，克罗恩病患者74例。采用第三代酶联免疫吸附试验检测抗丙型肝炎病毒抗体。对每位患者检测以下危险因素：炎症性肠病病程、结肠镜检查次数、手术史、输血史、静脉注射毒品史和免疫抑制治疗史。
丙型肝炎病毒血清阳性率为5.98%（7/117）。与丙型肝炎病毒血清学标志物独立相关的唯一危险因素是输血（优势比：7.77；置信区间：95%（1.63 - 49.09）；P = 0.012）。
炎症性肠病患者中丙型肝炎病毒感染患病率较高，主要原因是输血。未发现结肠镜检查和手术是丙型肝炎病毒感染的额外危险因素。
