将氢质子磁共振波谱成像（1H MRSI）与18氟脱氧葡萄糖正电子发射断层显像（18FDG-PET）相关联的方法。
Method to correlate 1H MRSI and 18FDG-PET.
作者信息
O'Neill J, Eberling J L, Schuff N, Jagust W, Reed B, Soto G, Ezekiel F, Klein G, Weiner M W
机构信息
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA.
出版信息
Magn Reson Med. 2000 Feb;43(2):244-50. doi: 10.1002/(sici)1522-2594(200002)43:2<244::aid-mrm11>3.0.co;2-2.
The in vivo neuronal contribution to human cerebral metabolic rate of glucose (CMRglc), measured by 18FDG-PET, is unknown. Examining the effect of 1H MRSI-derived N-acetyl aspartate (NAA) concentration on positron emission tomography (PET) measures of metabolic activity might indicate the relationship of CMRglc to neuron density. In a population of 19 demented, cognitively impaired, and control subjects, the Miller-Gartner algorithm was applied to whole-brain PET data to isolate the PET signal originating in cortical gray matter alone (GMPET). An analogous procedure applied to multislice proton MRSI data yielded the N-acetyl aspartate concentration in cortical gray matter (GMNAA). In 18 of 19 subjects, a significant linear regression (P < 0.05) resulted when GMPET was plotted against GMNAA, whereby GMPET was higher for higher GMNAA. This suggests that CMRglc rises linearly with increasing neuron density in gray matter. This method may be used to investigate the relationship of CMRglc to neurons in various conditions.
通过18FDG-PET测量的体内神经元对人类大脑葡萄糖代谢率（CMRglc）的贡献尚不清楚。研究1H磁共振波谱成像（MRSI）衍生的N-乙酰天门冬氨酸（NAA）浓度对正电子发射断层扫描（PET）代谢活性测量的影响，可能会揭示CMRglc与神经元密度之间的关系。在19名患有痴呆、认知障碍的受试者以及对照组受试者中，应用Miller-Gartner算法对全脑PET数据进行处理，以分离出仅起源于皮质灰质的PET信号（GMPET）。对多层质子MRSI数据应用类似程序，得出皮质灰质中的N-乙酰天门冬氨酸浓度（GMNAA）。在19名受试者中的18名中，当将GMPET与GMNAA绘制在一起时，得到了显著的线性回归（P < 0.05），即GMNAA越高，GMPET越高。这表明CMRglc随着灰质中神经元密度的增加而呈线性上升。该方法可用于研究在各种情况下CMRglc与神经元的关系。
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