[一般人群哮喘的遗传流行病学研究]

[Genetic epidemiological study of asthma in general].

作者信息

Jin Y, Chen C, Xu Y, Fang Z A

机构信息

Department of Environmental Health, Anhui Medical University, Hefei, China.

出版信息

Wei Sheng Yan Jiu. 1998 Jan;27(1):29-31.

PMID:10682633

Abstract

With theory and method of genetic epidemiology, data of 641 nuclear families on asthma were analysed, and the results showed that the history of parents asthma was one of risk factors about offsprings asthma, and the risk was 4.0-8.0 times higher (P < 0.01), compared with the one of offsprings of parents with no asthma. The effect of parents with asthma on the risk of sons was the same as one of daugters. The result declared that the airway responsiveness of parents did not relate to the one of offsprings. The results suggest that the genetic factors play an important role in the asthma.

摘要

采用遗传流行病学的理论和方法，对641个核心家庭的哮喘数据进行了分析，结果显示，父母有哮喘病史是子女患哮喘的危险因素之一，与父母无哮喘的子女相比，其风险高4.0 - 8.0倍（P < 0.01）。父母患哮喘对儿子和女儿患哮喘风险的影响相同。结果表明，父母的气道反应性与子女的气道反应性无关。这些结果提示，遗传因素在哮喘中起重要作用。