[A study of genetic epidemiology on child bronchial asthma].

OBJECTIVE

To examine the relationship between child bronchial asthma and genetic fastor.

METHODS

A case-control study including 372 pedigree was carried out.

RESULTS

Child bronchial asthma had obvious familiar clustering (chi 2 = 24.8, P < 0.01). The prevalence rate of the first and the second degree relatives of proband was significally higher than that of the controls. The segregation ration of asthma was 0.14 (95% CL 0.098-0.18). The h2 of the first and second degree relatives of asthma were 78.18% and 55.02%, of which 83.64% for female and 73.48% for male.

CONCLUSION

The genetic model of asthma belonged to polygenetics. Genetic fastor was a main risk fastor for asthma, especially for female patients.