Maki K C, Davidson M H, Cyrowski M S, Maki A C, Marx P
Chicago Center for Clinical Research, Illinois 60610, USA.
J Am Coll Nutr. 2000 Feb;19(1):23-30. doi: 10.1080/07315724.2000.10718910.
A predominance of small, dense low-density lipoprotein (LDL) particles (subclass pattern B) is associated with increased risk for coronary heart disease and is characterized by elevated triglycerides and depressed high-density lipoprotein (HDL) cholesterol concentrations. The present analysis was undertaken to assess the impact of LDL subclass distribution pattern and adiposity on serum lipids in postmenopausal women.
Anthropometric measurements and fasting lipid data were obtained from 254 postmenopausal women 70 years of age or younger, not receiving sex hormone replacement, who were participating in a clinical trial designed to assess the influence of hormone replacement regimens on coronary heart disease risk markers.
The prevalence of LDL subclass pattern B was 32%. Triglyceride levels were higher and HDL cholesterol lower (both p<0.001) in women with pattern B vs. pattern A, but total and LDL cholesterol levels did not differ. LDL subclass pattern contributed independently to the variance in HDL cholesterol (p<0.001) and log(e) triglyceride (p<0.001) concentrations explained by anthropometric variables (waist circumference or body mass index). Compared to women with LDL subclass pattern A and waist circumference below the median value of 83.0 centimeters, those with pattern B and waist > or =83.0 centimeters had markedly lower HDL cholesterol levels [44.0 (41.6-47.4) vs. 57.2 (54.1-60.3) mg/dL, mean (95% CI)] and increased triglyceride concentrations [geometric mean 147.8 (131.6-165.7) vs. 95.4 (88.2-102.5) mg/dL].
These data suggest that adiposity and LDL subclass distribution pattern are independent determinants of plasma triglyceride and HDL cholesterol concentrations in postmenopausal women.
小而密的低密度脂蛋白（LDL）颗粒占优势（B型亚类模式）与冠心病风险增加相关，其特征为甘油三酯升高和高密度脂蛋白（HDL）胆固醇浓度降低。本分析旨在评估LDL亚类分布模式和肥胖对绝经后女性血脂的影响。
对254名70岁及以下未接受性激素替代治疗的绝经后女性进行人体测量和空腹血脂数据采集，这些女性参与了一项旨在评估激素替代方案对冠心病风险标志物影响的临床试验。
LDL亚类B型模式的患病率为32%。与A型模式女性相比，B型模式女性的甘油三酯水平更高，HDL胆固醇更低（均p<0.001），但总胆固醇和LDL胆固醇水平无差异。LDL亚类模式独立影响HDL胆固醇的变异（p<0.001）以及由人体测量变量（腰围或体重指数）解释的log(e)甘油三酯浓度（p<0.001）。与LDL亚类A型模式且腰围低于中位数83.0厘米的女性相比，B型模式且腰围≥83.0厘米女性的HDL胆固醇水平显著更低[44.0（41.6 - 47.4）对57.2（54.1 - 60.3）mg/dL，均值（95%CI）]，甘油三酯浓度升高[几何均值147.8（131.6 - 165.7）对95.4（88.2 - 102.5）mg/dL]。
这些数据表明，肥胖和LDL亚类分布模式是绝经后女性血浆甘油三酯和HDL胆固醇浓度的独立决定因素。
