Gourley I M, Richards L W, Cordy D R
J Prosthet Dent. 1976 Nov;36(5):550-66. doi: 10.1016/0022-3913(76)90305-x.
Forty of 44 vented endosteal blade implants were well tolerated by the mandibular tissues of beagle dogs, as demonstrated clinically, radiographically, and histologically. Infection and inflammation were not observed. The epithelium did not invade along the neck of the implants more than 2 mm. below the mandibular crest. After 3 to 6 months, except for increasing density of bone at the metal interface, no distinct pattern of reaction could be discerned histologically. Except for heavy collagenous investment in three dogs, there was no sign of the implants being treated as sterile foreign bodies. In this study, histology did not provide good criteria for evaluating the failure of vented endosteal blade implants. In four implants which failed, the most reliable signs of failure were increased mobility and/or sulcus depth around the neck of the abutments. Radiographic evaluation of implants provided the best means of determining bone resorption. Bone resorption was apparent 3 to 6 months after implantation, did not appear to be progressive, and did not indicate implant failure or impending implant failure in those animals in which it occurred. Radiolucent areas observed in 29 of the specimens contained connective tissue, marrow spaces, thin bone trabeculae, and nonpathologic tissues. Although in some of the dogs stress on implants did not cause failure, there is a need for further experimentation involving vented endosteal blades subjected to occlusal loading.
44颗通气式骨内叶片种植体中有40颗在比格犬的下颌组织中耐受性良好，这在临床、影像学和组织学上均得到了证实。未观察到感染和炎症。上皮组织沿种植体颈部向下侵入下颌嵴以下不超过2毫米。3至6个月后，除金属界面处骨密度增加外，组织学上未发现明显的反应模式。除了三只狗的种植体周围有大量胶原纤维包裹外，没有迹象表明种植体被视为无菌异物。在本研究中，组织学并未提供评估通气式骨内叶片种植体失败的良好标准。在四颗失败的种植体中，最可靠的失败迹象是基台颈部周围的动度增加和/或龈沟深度增加。种植体的影像学评估是确定骨吸收的最佳方法。骨吸收在植入后3至6个月时明显，似乎没有进展，并且在发生骨吸收的动物中，这并不表明种植体失败或即将失败。在29个标本中观察到的透射区包含结缔组织、骨髓腔、细骨小梁和非病理性组织。尽管在一些狗中，种植体上的应力并未导致失败，但仍需要对通气式骨内叶片种植体进行进一步的实验，使其承受咬合负荷。
