Covinsky K E, Palmer R M, Counsell S R, Pine Z M, Walter L C, Chren M M
Department of Dermatology, The University of California, San Francisco and The San Francisco Veterans Affairs Medical Center, USA.
J Am Geriatr Soc. 2000 Feb;48(2):164-9. doi: 10.1111/j.1532-5415.2000.tb03907.x.
Retrospective reports of patients' functional status before hospital admission are often used in longitudinal studies and by clinicians caring for hospitalized patients. However, the validity of these reports has not been established. Our aim was to examine the validity of retrospective reports by testing hypotheses about the relationships these measures would have with other clinical measures if they were valid.
A prospective cohort study.
A total of 2877 older patients (mean age 81, 36% women) hospitalized on the general medical service at two hospitals. For 1953 of the subjects, the patient was the primary respondent, whereas for 924 subjects, a surrogate was the primary respondent.
Shortly after hospital admission, patients or surrogates reported whether the patient was independent in each of five activities of daily living (ADLs) on admission and at baseline 2 weeks before admission. Outcome measures included reported independence in each ADL 3 months after the hospitalization and survival to 1 year.
Patients' retrospective reports of their ADL function 2 weeks before admission had a clinically plausible relationship with ADL function at the time of admission, in that patients independent in an ADL on admission rarely reported they were dependent in that ADL 2 weeks before admission (range 2-6%). Surrogates were somewhat more likely than patients to report that patients independent on admission were dependent 2 weeks before admission (range 5-14%). Retrospective reports of prehospitalization ADL function demonstrated strong evidence of predictive validity for both patients' and surrogates' reports. For example, among patients dependent in bathing on admission, patients who were reported as independent 2 weeks before admission were much more likely than those reported as dependent 2 weeks before admission to be independent 3 months after hospitalization (68% vs 20%, P < .001 for patient respondents; 30% vs 5%, P < .001 for surrogate respondents). Similarly, among patients dependent in bathing on hospital admission, survival 1 year after hospitalization was much higher in patients who were independent in bathing 2 weeks before admission than patients who were dependent 2 weeks before admission (76% vs 59%, P < .001 for patient respondents; 60% vs 45%, P < .001 for surrogate respondents). Results were similar for each of the other four ADLs. In a logistic regression model controlling for the number of ADLs reported as dependent on admission, the number of ADLs reported as dependent 2 weeks before admission was significantly associated with 1-year mortality among both patient (odds ratio (OR) = 1.39 per dependent ADL, 95% confidence interval (CI) - 1.26-1.54) and surrogate (OR = 1.14, 95% CI = 1.06-1.24) respondents.
Hospitalized patients' assessments of their ability to perform ADLs before their hospitalization have evidence of face and predictive validity. These measures are strong predictors of important health outcomes such as functioning and survival. In particular, among patients dependent in ADL function on hospital admission, these results highlight the prognostic importance of inquiring about the patient's functional status before the onset of the acute illness.
患者入院前功能状态的回顾性报告常用于纵向研究以及照顾住院患者的临床医生。然而,这些报告的有效性尚未得到证实。我们的目的是通过检验关于这些测量指标若有效则与其他临床指标之间关系的假设,来检验回顾性报告的有效性。
一项前瞻性队列研究。
两家医院普通内科病房共收治了2877例老年患者(平均年龄81岁,36%为女性)。其中1953例患者由本人作为主要应答者,而924例患者由代理人作为主要应答者。
入院后不久,患者或代理人报告患者入院时及入院前2周基线时在五项日常生活活动(ADL)中的每项活动是否独立。结局指标包括住院3个月后报告的每项ADL的独立性以及1年生存率。
患者对入院前2周ADL功能的回顾性报告与入院时的ADL功能具有临床上合理的关系,即入院时某项ADL独立的患者很少报告入院前2周在该项ADL中依赖(范围为2% - 6%)。代理人比患者更有可能报告入院时独立的患者在入院前2周依赖(范围为5% - 14%)。入院前ADL功能的回顾性报告显示出对患者和代理人报告都有预测有效性的有力证据。例如,在入院时依赖洗澡的患者中,报告入院前2周独立的患者在住院3个月后独立的可能性远高于报告入院前2周依赖的患者(患者应答者中为68%对20%,P <.001;代理人应答者中为30%对5%,P <.001)。同样,在入院时依赖洗澡的患者中,入院前2周洗澡独立的患者住院1年后的生存率远高于入院前2周依赖的患者(患者应答者中为76%对59%,P <.001;代理人应答者中为60%对45%,P <.001)。其他四项ADL中的每项结果均相似。在一个控制了入院时报告为依赖的ADL数量的逻辑回归模型中,入院前2周报告为依赖的ADL数量与患者(比值比(OR)=每个依赖ADL为1.39,95%置信区间(CI) - 1.26 - 1.54)和代理人(OR = 1.14,95% CI = 1.06 - 1.24)应答者的1年死亡率均显著相关。
住院患者对其住院前进行ADL能力的评估具有表面效度和预测效度的证据。这些测量指标是功能和生存等重要健康结局的有力预测指标。特别是,在入院时依赖ADL功能的患者中,这些结果突出了在急性疾病发作前询问患者功能状态的预后重要性。