Mistlberger Andrea, Liebmann Jeffrey M, Greenfield David S, Hoh Sek-Tien, Ishikawa Hiroshi, Marmor Michael, Ritch Robert
Department of Ophthalmology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA.
Ophthalmology. 2002 Jul;109(7):1362-6. doi: 10.1016/s0161-6420(02)01070-9.
To compare optic disc topography and nerve fiber layer thickness in ocular hypertensive eyes and normal subjects.
Prospective, case-controlled study.
One eye in each of 20 normal and 27 ocular hypertensive patients was enrolled.
Consecutive normal and ocular hypertensive patients were enrolled. Each patient underwent complete ophthalmic examination, achromatic automated perimetry, short-wavelength automated perimetry, confocal scanning laser ophthalmoscopy, confocal scanning laser polarimetry, and optical coherence tomography. The intraocular pressure was 21 mmHg or less for normal subjects and at least 25 mmHg on two separate occasions in ocular hypertensive eyes. Structural parameters were compared between the two groups. Eyes with evidence of glaucomatous optic neuropathy, achromatic visual field loss, or evidence of focal visual field injury during short-wavelength automated perimetry were excluded.
Optic nerve head topography and nerve fiber layer thickness.
The three imaging technologies could not detect differences in optic disc or nerve fiber layer anatomy between the two groups. Ocular hypertensive eyes had a greater corrected pattern standard deviation than normal eyes during short-wavelength automated perimetry (P = 0.04).
Ocular hypertensive eyes with normal achromatic automated perimetry and short-wavelength automated perimetry could not be distinguished from normal subjects with confocal scanning laser ophthalmoscopy, confocal scanning laser polarimetry, and optical coherence tomography.
比较高眼压症患者与正常受试者的视盘地形图和神经纤维层厚度。
前瞻性病例对照研究。
纳入20名正常人和27名高眼压症患者，每人一只眼。
连续纳入正常人和高眼压症患者。每位患者均接受全面眼科检查、无色自动视野计检查、短波长自动视野计检查、共焦扫描激光眼底镜检查、共焦扫描激光偏振仪检查和光学相干断层扫描。正常受试者眼压为21 mmHg或更低，高眼压症患者两眼眼压在两个不同时间至少为25 mmHg。比较两组间的结构参数。排除有青光眼性视神经病变、无色视野缺损或短波长自动视野计检查中有局灶性视野损伤证据的眼。
视神经乳头地形图和神经纤维层厚度。
三种成像技术均未检测到两组间视盘或神经纤维层解剖结构的差异。在短波长自动视野计检查中，高眼压症患者的校正模式标准差高于正常眼（P = 0.04）。
无色自动视野计检查和短波长自动视野计检查结果正常的高眼压症患者，无法通过共焦扫描激光眼底镜检查、共焦扫描激光偏振仪检查和光学相干断层扫描与正常受试者区分开来。
