疱疹病毒信使核糖核酸通过依赖于染色体区域维护蛋白1（Crm1）和不依赖于Crm1的途径进行分类以便输出。
Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways.
作者信息
Soliman T M, Silverstein S J
机构信息
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
出版信息
J Virol. 2000 Mar;74(6):2814-25. doi: 10.1128/jvi.74.6.2814-2825.2000.
Abstract
Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.
摘要
细胞前体mRNA剪接受到单纯疱疹病毒调节蛋白ICP27的抑制，导致宿主蛋白质合成的关闭。在这里，我们揭示ICP27还通过依赖Crm1的途径介导一些病毒RNA的输出，并提供证据表明这些功能需要独立的结构域。一些病毒mRNA的核输出分选需要Crm1，而其他病毒mRNA则通过另一种途径输出。
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